The Importance of A GMP Certification

A supplier should hold GMP (Good Manufacturing Practices) certification in order to ensure safe and qualitative packaging. Hence our drugdu (Ddu) has collaborated with world-class Pharmaceutical Machinery Packaging and Materials Supplier named 'Jiangyin Tejie Rubber & Plastic Co., Ltd., in order to deliver sturdy, user-friendly machineries available in varied capacities with minimal power consumption.

'Jiangyin Tejie Rubber & Plastic Co., Ltd.

This China based Pharmaceutical Machinery Packaging and Materials Supplier produce pharma based packaging materials for antibiotics, infusion, blood collection tubes, freeze drying and polyisoprene gasket. They are specialized in producing 3 billion ISO9001 certified butyl rubber stoppers every year. Their major products include Teflon coated injection vial rubber stopper, PP or PE Euro cap for infusion container, flip off cap, glass bottle rubber stopper, lyophilization rubber stopper etc. The products were exported to Africa, America, Europe, Middle East and South East Asia.

This company has got 20 years of R&D and production experience of pharma packaging materials. As per the international GMP sterilization standards, their production unit is well equipped with a 300,000-grade vulcanizing room, a 100,000-grade trimming room, a 10,000-grade cleansing and 100-grade packing room. They have also introduced high-speed detection equipment to ensure the quality of stoppers.

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Status quo analysis of lung diseases with necessity of pulmonary function tests

According to the World Health Organization, more than half (54%) of the world's 56.4 million deaths in 2015 were caused by ten major health issues including heart disease, accidents and cardiovascular-cerebrovascular diseases. Among them, respiratory diseases take up quite a large portion. As can be seen from the figure below, slow-resistance lung issues caused about 3.2 million deaths in 2015, while lung cancer (with tracheal and bronchial cancer) caused about 1.7 million deaths. During this same period, the number of deaths resulting from tuberculosis decreased but was still responsible for an estimated 1.4 million deaths, which is why this disease also ranked among the top ten causes of death. Therefore it is obvious that repertory diseases still pose a major threat and lung function examinations are as urgent as ever

Today, we focus on the situation within South America. From the chart below, it can be seen that in Colombia and Argentina (whose populations rank second and third respectively in South America) chronic obstructive pulmonary disease or chronic respiratory disease were among the top five causes of death. Further data also shows that in countries with high populations and per-capita GDP such as Brazil, Chile, Cuba, Peru, Mexico, Uruguay and Venezuela, death caused by chronic obstructive pulmonary disease (COPD) are also ranked in the top ten.

The situation is equally grim within China. Data from previous analyses show that COPD ranked as the third highest cause of death.

Nanshan Zhong, director of the Guangzhou Institute of Respiratory Diseases and academician of the Chinese Academy of Engineering, pointed out that COPD has become the third leading cause of death after cancer and cerebrovascular diseases. However, because there are almost no symptoms in the early stages, people are generally less aware of the disease and often ignore or even pass the necessary tests. Currently, regular pulmonary function tests are still the simplest and most effective screening method for COPD, and make it a habit to regularly test for the disease in the same way that we regularly test blood pressure.

Regular pulmonary function tests are one crucial to detect respiratory diseases. It is mainly used to detect the patency of the respiratory tract and lung volume. For early detection of lung and airway diseases, assess the severity and prognosis of the disease, assess the efficacy of drugs or other treatment methods, identify the causes of dyspnea and diagnose the positions of lesions. It has important clinical value in assessing the tolerance of lung functionality for surgery or labor intensity tolerance and monitoring of critically ill patients.

In the not so distant past, we had to go to the hospital for regular pulmonary function tests via a large pulmonary function meter. Nowadays, there are a variety of portable lung function meters on the market which is convenient for real-time measurement at home. Below are two portable lung function monitors available in drugdu.com.

1. KANGTAI SP10

Main measuring parameters: FVC FEV1 PEF

Method of measuring induction: Turbine

Features: Bluetooth, KANGTAI Cloud Health App

Price: 3000 RMB for Bluetooth version, mainly for export

2. HUXIJIA A1

Main measuring parameters: FVC FEV1 PEF

Method of measuring induction: Shrapnel

Features: Bluetooth, Mobile data, HUXIJIA app, Computer doctor end

Price: 1980 RMB

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Chinese Farms to Face Emergency Inspections Following Swine Fever Outbreak

Reports of the country’s first African swine fever case in China’s Liaoning province sparked increased inspections at pig farms and markets and beefed up the scrutinizing of hog transportation.
The African swine fever outbreak puts the hog farming industry in the province and the entire country in great peril, and must be exterminated scrupulously, an official from Liaoning Provincial Bureau of Animal Health and Production said, according to Liaoning Daily.

The provincial government has instructed local heads to initiate emergency inspections at all pig farms, hog markets, slaughterhouses and harmless treatment locations in the province, and note any instances of pig deaths owing to unidentified reasons, butchered pigs found with splenomegaly or splenic haemorrhage, and immune failure amid pigs post swine fever vaccines, reported the paper, quoting the animal health bureau.

A provisional shutting of all live hog markets and slaughterhouses in Shenbei district has been ordered, where the outbreak was revealed, the paper reported.

About 913 hogs were culled near Shenyang, the capital of Liaoning, and forbid shipping of hogs from the affected areas, after the outbreak.

Transport of Hogs and products in Shenyang is restricted within the city and those shipped from exteriors must undergo stringent quarantine, the animal health bureau official said.

This being the first case in East Asia has raised concern about its spread in China, which possesses the world’s largest pig herd, and probably to adjacent countries in Asia.

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Top 5 Chinese Cities Producing Medical Device Products

China's medical device market is growing at a rate of 20% a year, with more than 15,000 medical device manufacturers and 40,000 medical device traders. Often specific regions in the country have centralized manufacturing with higher production schedule efficiency of medical device products. Here are China’s 5 major medical device cities:

Tonglu, Zhejiang

Tonglu has become the distribution center of domestic endoscopes. There are more than 30 Manufacturing Enterprises officially registered, and more than 90 trading companies.

Xuzhou, Jiangsu

There are 53 medical device manufacturers and 434 medical device distributors in Xuzhou, most of which are small-scale enterprises. The main products include anorectal treatment instruments, prostate treatment instruments, B-ultrasound and other low-end medical device products.

Touqiao Town, Yangzhou, Jiangsu

Yangzhou is a well-known area for disposable medical consumables in China, with a staff of 6,200 and nearly 5,000 marketers. Products are mainly concentrated on disposable medical supplies, including anesthesia kits, puncture kits, infusion devices and others.

Wuhan, Hubei

Wuhan occupies the majority of the medical laser equipment market share in China and is the leader in the domestic market in terms of cutting-edge products. There are currently dozens of medical laser manufacturers in Wuhan.

Jinxian county, Jiangxi

Jinxian county has more than 150 medical device product manufacturers and more than 300 trading companies, accounting for 31% of the country's market share. It mainly produces and sells disposable infusion sets, syringes, needles, medical hygienic materials, and dressings.

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Study Unravels New Protein Complex that Repairs Broken DNA Ends

In a major breakthrough in cancer research, a team of scientists from the University of Toronto, The Institute of Cancer Research, London, The Netherlands Cancer Institute and the University of Bern have discovered how cells repair damaged strands of DNA. They revealed a brand new protein complex in cells that protect broken DNA ends and causes its repair, in their study published in Nature on Wednesday.

Promising new drugs called PARP inhibitors or platinum-based chemotherapies to target the same type of DNA repair system that this complex, named as ‘Sheildin’ complex, activates for use in cancer cells. It was also found to be involved in the production of precise antibodies in an immune response and thus, mutations could lead to immune-related disorders.

The discovery could guide investigations to project and monitor treatment for patients with mutations in BRCA1, BRCA2 or other DNA repair genes, treated with platinum-based chemotherapies or exciting new drugs called PARP inhibitors which cash in upon the inability of cancer cells to repair their DNA.

The Shieldin complex, when intact, attaches itself to the broken DNA, compelling cancer cells to try to repair their DNA in a manner that renders them susceptible to PARP inhibitors and platinum chemotherapies. However, any mutation leads to immediate resistance to PARP inhibitors.

Study lead author and professor at the University of Toronto, Daniel Durocher said, "PARP inhibitors hold great promise for breast and ovarian cancer treatment, but we must understand why they sometimes don't work, or stop working altogether. Knowing more about how cancer evades PARP inhibition by studying basic DNA repair mechanisms brings us a big step closer to this objective, which will improve how we treat some of the most intractable cancers." 

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China’s Import and Export Report of Peptic Ulcer Drugs

Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. The most common symptom of a peptic ulcer is stomach pain.

There is an increasing number of people with irregular diets due to the accelerated pace of modern life. Thus, more and more people suffer from peptic ulcer diseases, stimulating the need for peptic ulcer drugs.

Today, Ddu, the leading global pharmaceutical & medical device B2B online platform, will be sharingChina’s Import and Export Report of Peptic Ulcer Drugs with you.

I. Global situation of peptic ulcer drugs market

The sales of peptic ulcer drugs account for the biggest part of digestive system drugs and according to the classification of the European Pharmaceutical Research Market Association, they can be divided into the following 5 categories:

Proton Pump Inhibitor

H2-antagonists

Bismuth Preparations

Prostaglandins

Others

According to IMS statistics, the global market of peptic ulcer drugs in 2016 was 20.83 billion USD. The market share of the main products are shown in the following chart.

Source: IMS

PPI became the main treatment for ulcers due to its fast-acting, long-lasting effects and good acid suppression.

The global proton pump inhibitor (PPI) market was 18.146 billion USD in 2016, accounting for 87.2% of the global market for peptic ulcer drugs.

In addition to this, omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole were the leading products in peptic ulcer drugs market.

Source: PDB, CNKI

Currently, the key markets for peptic ulcer drugs are Europe, North America and Asia.

The Chinese market ranked first amongst the Asian markets with 1.125 billion USD. The chart below indicates the markets for other regions.

Source: PDB, CNKI

II. Chinese peptic ulcer drugs market

Different from those in global markets, peptic ulcer drugs in the Chinese market are mainly divided into the following categories:

Proton Pump Inhibitors

H2-antagonists

Mucosal Protective Agents

Others

According to the statistics of PDB, the Chinese peptic ulcer drugs market is growing year by year with a market size exceeding 7.43 billion RMB in 2016 and is expected to reach 8 billion RMB in 2017.

2014-2017 Growth Trend of Global Market of Anti-Peptic Ulcer Drugs (100 Million RMB)

Proton pump inhibitors (PPI) accounted for 91.8% of the Chinese peptic ulcer drugs market H2-antagonists 4.3%, Mucosal Protective Agents 2.1% and others 1.8%.

As indicated on the chart below, PPIs dominate the market followed by omeprazole for injection (45%), pantoprazole for injection (37%), lansoprazole for injection (12%) and esomeprazole for injection (6%).

Source: PDB

According to the statistics of PDB, public hospitals in major cities in China spent 4.5 billion RMB on PPIs in 2016, an increase of 6% over the previous year. Lansoprazole ranked first with market sales of 1.239 billion RMB, an increase of 5.52 %.

III. China’s imports of peptic ulcer drugs

Domestically manufacture generic drugs are taking the place of imported peptic ulcer drugs. Thus, imported peptic ulcer drugs only accounted for 16.7% of the peptic ulcer drugs market with a total import of 1.24 billion RMB.

China mainly imported esomeprazole, omeprazole and hydrotalcite from AstraZeneca and Bayer.

PPI esomeprazole (Nexium) from AstraZeneca took up a comparatively big share of China’s imported drugs. The chart below indicates China’s peptic ulcer drug imports of 2016.

Source: PDB

IV. China’s export of peptic ulcer drugs

With the encouragement of the national industrial policy and the support of technological developments, China’s export market of peptic ulcer drugs is developing rapidly with growing exports.

According to the statistics of China custom, exports of pantoprazole sodium and omeprazole are as follows:

Source: China Custom

V. Chinese leading peptic ulcer drugcompanies

•  Cisen Pharmaceutical Co., Ltd

Cisen Pharmaceutical Co., Ltd is a comprehensive chemical manufacturing enterprise in China, one of the top 100 Chinese pharmaceutical industry companies and a national high-tech company.

Representative product: Pantoprazole sodium enteric-coated tablets, omeprazole for injection, omeprazole enteric-coated tablets and Lansoprazole tablets

Indications: Duodenal ulcer and gastric ulcer

Main exporting regions: Pakistan, Angola, Venezuela, Nicaragua and others

• Jiangsu Aosaikang pharmaceutical Co., Ltd

Jiangsu Aosaikang pharmaceutical Co., Ltd is a research-based pharmaceutical enterprise that integrates and streamlines innovative research and development with manufacturing, marketing promotions and sales of proprietary pharmaceuticals, fine chemicals and health care products.

Representative product: Omeprazole sodium for injection and lansoprazole for injection

Indications: Peptic ulcer and hemorrhage

Main exporting regions: USA

• Youcare Pharmaceutical Group Co., Ltd.

Youcare Pharmaceutical Group Co., Ltd. is involved in drug research and development, pharmaceutical manufacturing, distribution and sales, and foreign trade as one of the private pharmaceutical enterprise groups.

Representative product: Omeprazole enteric-coated capsules

Indications: Gastric ulcer and duodenal ulcer

Main exporting regions: More than 40 countries and regions such as Russia, Pakistan, Germany, Africa, Latin America

VI. There is a great potential market for pantoprazole

Due to social development, environmental changes, population structures and people's lifestyles, the incidence of peptic ulcers caused by smoking, drinking, emotional stress and drug stimulation is getting higher and higher. In China and around the world, the number of patients with peptic ulcer disease is rapidly increasing. Thus, prevention and treatment of peptic ulcer disease has become an urgent matter.

Ddu, the leading global pharmaceutical & medical device B2B online platform, believes that pantoprazole, as a new generation of proton pump inhibitors, is more stable than that of mono alkoxyl pyridine and has better selective effect on parietal cells. Moreover, compared with omeprazole and lansoprazole, pantoprazole is safer and more effective when used in combination with other drugs and has good anti-acid secretion effects. Therefore, pantoprazole is a highly selective H+，K+-ATP enzyme inhibitor with good curative effects and minimal side effect.

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China’s Import and Export Market Report of Contraceptive Drugs

Research by the World Health Organization has shown that“Physically, it is much more difficult to stop the production of millions of sperm per day for men than to prevent women from releasing an egg every month.”

In the contraceptive drugs market, contraceptive drugs for women account for 90%, and is gradually becoming just as accepted in China as it is in most other parts of the world.

Contraceptive drugs can be divided into short-acting oral contraceptives, contraceptives for topical use, long-acting oral contraceptives and emergency contraceptives according to the directions and efficacy.

Today, Ddu, the leading global pharmaceutical and medical device B2B online platform, will share China’s Import and Export Market Report of Contraceptive Drugs with you.

I. General situation of the global contraceptive drugs market

According to the statistics of the UN database, the major areas of global consumption of contraceptives are mainly distributed across North America, Asia and the European Union with the main countries being the United States, Belgium, Russia, Canada and the United Kingdom.

However, due to the economic and cultural differences, women in different countries and regions have adopted different contraceptive methods and oral contraceptives are generally preferred by women in developed countries. German, for example, women use oral contraceptives for an average of 6.5 years, in France, 5.6 years, and in the United Kingdom, 5.5 years.

According to the International Planned Parenthood Federation (IPPF), oral contraceptives, which are characterized by their high efficacy, low side effects and good cycle regulation, can also improve women's skin condition and bleeding patterns and are being used by more and more women of childbearing age. At the same time, scientists are constantly working hard to develop more safe and effective oral contraceptives.

II. China’s market of contraceptive drugs

In recent years, the contraceptive drugs market has been expanding with an increasing demand for contraception due to raised awareness of healthy reproduction.

According to PDB statistics, the contraceptive drugs market in China reached 3.39 billion Yuan in 2016, an increase of 3.8% from 2015. Additionally, the market share of short-acting oral contraceptives, long-acting oral contraceptives, emergency contraceptives and contraceptives for topical use was 6%, 0.4%, 69.6% and 4% respectively.

Emergency contraceptives ranked first in China's contraceptive drugs market with a huge market share followed by short-acting oral contraceptives.

Although short-acting oral contraceptives didn't take up the largest market share of contraceptives in China, their potential for development is worth looking into. Since they were released onto the market in the 1960s, short-acting oral contraceptives have undergone various changes from generation to generation. As their drug structure was continuously optimized, contraceptive efficiency gradually enhanced and side effects reduced, they were welcomed by women in Europe and the United States.

III. China’s import of contraceptive drugs

Although there is great market potential for oral contraceptives, there is a noticeable lack of high quality contraceptive products in China. Currently most domestic companies lack the necessary market awareness and with only single product structures and weak independent research and development capabilities (including secondary product development), China has not yet formed proper R&D entities and thus needs to import foreign high-quality products to meet the demands of the domestic market.

At present, as indicated on the chart below, the market segment of the domestic oral contraceptive market and the imported drugs market is very distinct Yu Ting, emergency contraceptives from Zizhu Pharma, is the top representative of domestic contraceptive drugs while Yasmin and Diane-35, short-acting oral contraceptives from Bayer Healthcare, are the main imported contraceptive drugs.

IV. China’s contraceptive drugs exports

It is estimated that China has about 350 million women of childbearing age in need of contraception, creating huge market capacity. Due to the continuous improvement of the family planning policy and social call, population control has drawn great attention from medical professionals. The result of this is that many pharmaceutical companies have become involved in the production of contraceptives and some of them have developed international markets. According to the data of China customs, China's contraceptive drug exports in 2016 was 11,758,000 USD and the major export products were as follows:

V. Domestic leading contraceptive drug companies

a. Zhejiang Xianju Pharmaceutical Co., Ltd.

Zhejiang Xianju Pharmaceutical Co., Ltd., domestic professional manufacturer of steroid drugs, is a designated drug producer of national family planning and a key high-tech enterprise of the National Torch Program.

Representative drugs: Yiting (Levonorgestrel Tablets)

Indication: Emergency contraception for women

Main exporting areas: USA, European Union, South Korea, Colombia and other countries

b. Shanghai pharmaceutical(Sine) Co,. Ltd.

One of the earliest ethnic chemical and pharmaceutical companies in modern China an industrial entity of the Chinese chemical pharmaceutical companies with the most products and formulations.

Representative drugs: Yiting (Levonorgestrel Tablets)

Indication: Emergency contraception for women

Main exporting areas: USA, UK, Canada, Australia and other countries

c. Regenex Pharmaceuticals. Co,. Ltd.

High-tech pharmaceutical company engaged in R&D, production and sales of reproductive health drugs, chronic drugs and external drugs.

Representative drugs: Danmei (Levonorgestrel Enteric-coated Tablets)

Indication: Emergency contraception for women

Main exporting areas: USA

IV. Short-acting oral contraceptives may be the new favorite of market

As one of the most effective methods to prevent a pregnancy after unprotected sex, the market is sure to grow. Moreover, the research on contraceptives in the market mainly follows three principles: effectiveness, less estrogen and side effects. Thus, Ddu, the leading global pharmaceutical & medical device B2B online platform, suggests that due to the distinct market potential, there is ample opportunity to explore and develop the short-acting oral contraceptive market in China. As a results of the rise in awareness of the benefits of these short-acting contraceptives, it won’t be long before they replace emergency contraceptives to become the new favorite in the Chinese market.

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